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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2003 August;162(4):97-100
Phytoestrogens and tamoxifen citrate interferences in treatment of breast cancer: a literature review
Fiorenzuoli F., Gori L., Corti G., Manetti M.
Centro di Medicina Naturale, Ospedale S. Giuseppe, Az USL 11 Empoli, Firenze
Phytoestrogens are substances derived from vegetals that, from a phytochemical point of view, have an estrogenic activity, and belong to the group of isoflavones. Phytoestrogens are sold as over the counter products in alimentary integrators and herbal foodstuff, and are used for the treatment of menopause-related diseases. They are mostly extracted from soy (Glicine Max, Merril), red clover (Trifolium pratense, L), alfalfa (Medicago sativa, L), black cohosh (Cimicifuga racemosa, L. Nuttal). Because of their estrogenic activity, they can cause interferences with the pharmacological activity of Tamoxifen citrate, an antiestrogenic drug of common use in the treatment of estrogen-dependent breast cancer.