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Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Online ISSN 1827-1812
Bertuccio S. N. 1, Pellicanò S. 2, Calzone R. 1, Bertuccio A. 1, Del Giudice A. C. , Rombola F. 1, Rizza R. 1
1 Divisione di Malattie Infettive, Ospedale Civile “G. Jazzolino”, ASL n. 8, Vibo Valentia;
2 Divisione di Malattie Infettive, Ospedale “S. Giovanni di Dio”, ASL n. 5, Crotone
Chlamydia pneumoniae (CP) is a common respiratory tract pathogen. In Sweden, the majority of adults have serological evidence of previous exposure. Most infections are probably asymptomatic or subclinical. The most common clinical manifestations of pneumonia due to CP are fever, cough, chest pain and shortness of breath. Cases of CP infections in patients with non specific interstitial pneumonia (NSIP), pityriasis rosea and erythema nodosum are recently described. It was hypothesized that recurrent infection caused by CP may play a role in the pathogenesis of NSIP and in atherosclerotic vascular lesions. The acute form is normally most frequent in elderly patients. The IgM and IgG research may help to differentiate the acute from the previous infection and the primary infection from reinfection. In a study of 111 patients, IgG1 subclass - specific antibodies to CP were found in all subjects enrolled. We describe a case of a young man, 40 years old, without other pathologies, immunodepression and apparent causes of interference as reumathoid factor, dialytic treatment and drugs; IgG present an anomalous behaviour because rather than increase, as usual they were preciously reduced. This behaviour, at present rarely described in the literature, usually is associated with erythema nodosum and pityriasis rosea.