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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE

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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2003 June;162(2-3):67-9

language: Italian

Pneu­mo­nia due to chla­myd­ia pneu­mon­i­ae ­with anom­a­lous ­antibody’s ­answer

Bertuccio S. N. 1, Pellicanò S. 2, Calzone R. 1, Bertuccio A. 1, Del Giudice A. C. , Rombola F. 1, Rizza R. 1

1 Divisione di Malattie Infettive, Ospedale Civile “G. Jazzolino”, ASL n. 8, Vibo Valentia;
2 Divisione di Malattie Infettive, Ospedale “S. Giovanni di Dio”, ASL n. 5, Crotone


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Chla­myd­ia pneu­mon­i­ae (CP) is a com­mon res­pir­a­to­ry ­tract patho­gen. In Swe­den, the major­ity of ­adults ­have ser­o­log­i­cal evi­dence of pre­vi­ous expo­sure. ­Most infec­tions are prob­ably asymp­to­mat­ic or sub­clin­i­cal. The ­most com­mon clin­i­cal man­i­fes­ta­tions of pneu­mo­nia due to CP are ­fever, ­cough, ­chest ­pain and short­ness of ­breath. Cas­es of CP infec­tions in ­patients ­with non spe­cif­ic inter­sti­tial pneu­mo­nia (­NSIP), pit­y­ri­a­sis ­rosea and ery­the­ma nodo­sum are recent­ly ­described. It was hypoth­e­sized ­that recur­rent infec­tion ­caused by CP may ­play a ­role in the path­o­gen­e­sis of ­NSIP and in ath­e­ros­cle­rot­ic vas­cu­lar ­lesions. The ­acute ­form is nor­mal­ly ­most fre­quent in eld­er­ly ­patients. The IgM and IgG ­research may ­help to dif­fer­en­tiate the ­acute ­from the pre­vi­ous infec­tion and the pri­mary infec­tion ­from rein­fec­tion. In a ­study of 111 ­patients, IgG1 sub­class - spe­cif­ic anti­bod­ies to CP ­were ­found in all sub­jects ­enrolled. We ­describe a ­case of a ­young man, 40 ­years old, with­out oth­er pathol­o­gies, immu­nod­e­pres­sion and appar­ent caus­es of inter­fer­ence as reuma­thoid fac­tor, dia­lyt­ic treat­ment and ­drugs; IgG ­present an anom­a­lous behav­iour ­because rath­er ­than ­increase, as usu­al ­they ­were pre­cious­ly ­reduced. ­This behav­iour, at ­present rare­ly ­described in the lit­er­a­ture, usu­al­ly is asso­ciat­ed ­with ery­the­ma nodo­sum and pit­y­ri­a­sis ­rosea.

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