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CURRENT ISSUEGAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE

A Journal on Internal Medicine and Pharmacology


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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2002 December;161(6):237-41

 THERAPEUTICAL NOTES

Effect of a calcium and vuitamin D supplementation on bone turnover

Bianchi M. L., Galbiati E., Dubini A., Saraifoger S., Cherubini R., Ortolani S.

Centro Malattie Metaboliche Ossee, Istituto Auxologico Italiano, IRCCS, Milano

Background. To evaluate the effects of a modest calcium and vitamin D supplementation on the main parameters of bone turnover.
Methods. 13 post-menopausal women with a low bone mass taking a daily supplement of calcium (285 mg) and vitamin D (120 UI) were studied. The following parameters were measured: (on serum) total and ionized calcium, phosphatemia, creatinine, parathyroid hormone (PTH), bone-specific alkaline phosphatase (BSAP), osteocalcin (OC), C-terminal telopeptide (CTx); (on urine) calcium, creatinine, N-terminal telopeptide (NTx).
Results. Calcium serum levels, both ionized and total, and calcium urinary excretion were significantly increased after 3 months of supplementation. On the contrary, the serum levels of PTH and the bone reabsorption markers (serum CTx and urine NTx) showed a significant reduction. Serum phosphate levels and bone formation markers (BSAP and OC) did not show any relevant change.
Conclusions. The study has shown that even a modest increase in the daily intake of calcium and vitamin D can determine a reduction of PTH levels and bone resorption indexes in post-menopausal women with a reduction of bone mass. These changes, if maintained in the long term, could help in controlling the increase of bone resorption that is often present in these patients.

language: Italian


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