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Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Online ISSN 1827-1812
Mukhtar A., Taha S. A.
Department of Urology, College of Medicine, King Faisal University, Damman, Saudi Arabia
Renal calculi (kidney stones, nephrolithiasis) are abnormal concentrations occurring in the kidneys, consisting of cristalline and an organic matrix. The protein affects the osmolarity and concentration of the urine and has some pathological effects on kidney diseases. Urine protein electrophoresis is a procedure that is used in all laboratories. A modified technique for urine samples precipitation (room temperature precipitation technique, RTPT) was applied in Bahrain Defence Force Hospital. Fifty-two urine samples (10-30 cc) were collected from patients with renal calculi attending the nephrolithiasis clinic in King Fahad University Hospital in Al Khobar, Kingdom of Saudi Arabia, from September 2001 to April 2002. Thirty-six urine samples (10-30 cc) from healthy persons without any history of renal calculi or diseases were also collected as a control group. The utilization of RTPT method for α2 protein molecule estimation in the urine samples of renal calculi patients (43-72%) revealed some different bands than urine of healthy persons (4-9%). It is clear that this technique is sensitive and specific to determine the protein molecules in the urine of renal calculi patients. An interesting finding was the difference of β protein in the urine sample of a case with left lower uretary stone and schistosomal ureteritis and ureter carcinoma which was 58% compared to healthy persons (5-12%).