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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2002 October;161(4-5):177-81
Can self application of zinc sulphate and usnic acid cream improve the outcome of vulvoperineal HPV infection?
Mancino P., Roma B., Melluso J., Onorati E., Russo P., Monti M.
Department of Gynaecological Sciences, Perinatology and Puericulture, University of Rome “La Sapienza”, Rome
Background. To evaluate the effectiveness of zinc sulphate and usnic acid as a topical ther-apy in women affected by vulvoperineal HPV infection.
Methods. Between October 1998 and December 1999, 76 women with colposcopic, cytological and histological diagnosis of vulvoperineal HPV lesions were studied. These women were treat-ed by self-application of zinc sulphate and us-nic acid cream at the following administration: 2 daily applications for 30 days, a drug free period of 10 days and other 2 daily applications for 30 days. The patients were followed up at 1 month, 3 months and 6 months.
Results. A 25% complete recovery (CR) was reported after 1 month of therapy, 61,8% CR after 3 months and 77.6% after 6 months.
Conclusions. The role of topical medical therapy for vulvoperineal HPV infection remains limited in effectiveness if compared to the physical-destructive therapy. However, the results obtained, especially after 3 and 6 months from the treatment, show that zinc sulphate and usnic acid cream could be considered a valid therapeutic strategy to reduce the extension of the vulvoper-ineal HPV lesions and prevent recurrences.