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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE

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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2002 June;161(3):119-21

language: English

Thrombotic events in cancer, not only paraneoplastic signs. A case report

Niglio A. 1, Di Micco P. 1, Chirico G. 1, Di Giuseppe D. 1, Russo F. 1, De Vita F. 2, Torella R. 1

1 Department of Geriatrics, Gerontology and Metabolism Diseases, Division of General Medicine;
2 Division of Oncology, Second University of Naples, Naples, Italy


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We ­report a ­case of ­deep ­vein throm­bo­sis of the ­right leg occur­ring in a 56-­year-old man ­with ­lung can­cer. ­Deep ­vein throm­bo­sis was treat­ed ­with unfrac­tioned hep­a­rine, but throm­bo­phil­ia was per­sis­tent ­also ­after its ther­a­py and was tes­ti­fied by ­high plas­ma ­rate of pro­throm­bin 1+2 frag­ment (F1+2). ­Lung can­cer was in ­local ­advanced ­stage (T3N0M0). Chem­o­ther­a­py was per­formed ­with gem­cit­a­bi­ne and car­bo­plat­i­num for treat­ment of ­lung can­cer. ­This ­case sug­gests ­that ­there is a throm­bo­phil­ic ­state in nat­u­ral his­to­ry of the onco­log­i­cal dis­ease and can­cer is the ­most com­mon ­acquired ­cause of throm­bo­sis. Throm­bo­sis can ­occur as an ear­ly or ­late ­sign of the dis­ease, ­because ­many mech­a­nisms are ­involved in can­cer relat­ed vas­cu­lar throm­bo­sis.

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