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A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2002 June;161(3):109-11
COX-2 Inhibitors in allergy
U.O. Medicina Interna, Azienda Ospedaliera «Gravina» - Caltagirone (CT)
Background. Pseudoallergic reactions triggered by acetyl salicylic acid and nonsteroidal anti-inflammatory drugs are common and caused by inhibition of the cyclooxygenase-1, whereas their therapeutic effects are mediated by inhibition of cyclooxygenase-2. Paracetamole and codeine are safe alternative analgesics for analgesic intolerant patients. The aim of this study was to determine the safety and tolerability of selective cyclooxygenase-2 inhibitors in patients with intolerance reactions to aspirin-intolerance.
Methods. In 18 patients with rheumatic diseases and ASA-intolerance, the oral administration of Celecoxib and Rofecoxib was tolerated without adverse effects.
Results. Recent results suggest that aspirin sensitivity may be linked to the cyclooxygenase-1 pathway, and cyclooxygenase-2 inhibitors, as a result of their selectivity, may be beneficial in this group of patients.
Conclusions. The use of selective cyclooxygenase-2 inhibitors represents a therapeutic alternative as well as a means to prevent the described reactions.