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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2002 April;161(2):105-8
Use of quaternary ammonium salts in the treatment of bacterial vaginosis
Mancino P., Onorati E., Roma B., Russo P., Monti M.
Policlinico Umberto I, Dipartimento di Scienze Ginecologiche, Perinatologia e Puericultura, IV Divisione - Roma, Università degli Studi «La Sapienza» - Roma
Background. Bacterial vaginosis comprises a heterogeneous group of lower genital tract infections of bacterial polymicrobial origin characterized by alterations in the vaginal ecosystem with substitution of the normal lactobacilli flora by pathogenic microorganisms. The objective of the study was to evaluate the effectiveness of quaternary ammonium salts in the treatment of these infections.
Methods. The study group consisted of 75 women (age range, 20-65 years) with bacterial vaginosis or mixed vulvovaginitis. The patients received a 10-day course of treatment with Bergagyn ovules (benzalkonium chloride) and Alfa Bergamon external douche. Bacteriological and clinical examinations were performed one mounth from the end of treatment.
Results. At one mounth after treatment with quaternary ammonium salts patients reported relief of symptoms, especially reduction in vulvar and vaginal pruritis and malodorous leukor-rhea; clinical signs of bacterial vaginosis had improved in 27% of patients. Remission of symptoms was found in 64% of patients. Only 9.3% did not respond to therapy.
Conclusions. Local treatment with quaternary ammonium salts was found to be effective in the reduction of symptoms and clinical signs of bacterial vaginosis, with good bactericidal and bacteriostatic action. Overall effectiveness was 90%, including cases of improvement without complete remission of symptoms. Furthermo-re, treatment was well tolerated and compliance was excellent, with few side effects limited to mild local intolerance.