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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2002 April;161(2):101-4
Ginkgo Biloba extract with magnesium and L-arginine in the Alzheimer disease: a new therapeutic approach
Cucca S., Martechini A., Musolino F.
Ospedale al Mare, Lungodegenza, Lido di Venezia, Venezia
Background. This study aimed to evaluate, in mildly to moderately demented patients with Alzheimer disease (AD), the efficacy of both Ginkgo biloba extract with magnesium plus L-arginine and a non-pharmacological approach based on Reality Orientation Therapy (ROT).
Methods. Three homogeneous groups of patients with mild to moderate AD, 46 subjects in total, were assessed by Mini Mental Status Examination (MMSE) at the baseline check-up, and after 6 and 12 months. Group A composed of 16 subjects, was treated with Ginkgo biloba, magnesium and L-arginine association for a period of 12 months; Group B 15 subjects, received three cycles of formal ROT at the first 4th and 8th month; Group C, composed of 15 subjects, acted as a Control Group.
Results. In the group treated with Ginkgo biloba, magnesium and arginine, the MMSE score showed a small improvement at the sixth month and a slight, no significant decrease at the twelfth month. In the ROT group, the MMSE score decreased both at the sixth and at the twelfth month but in a no significant way Finally, in the control group the MMSE score showed a remarkable and statistically significant decrease.
Conclusions. Reality Orientation Therapy, and especially, Ginkgo biloba-magnesium-arginine association, appear to be able to slow down the negative evolution of AD. We recommend these two treatments in association.