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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE

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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2002 February;161(1):7-18

Copyright © 2002 EDIZIONI MINERVA MEDICA

language: English

Intercompartmental, plasma and urinary biochemical changes in healthy subjects during acute and rigorous bed rest and ambulation

Zorbas Y. G. 1, Yarullin V. L. 1, Denogratov S. D. 2, Kuznetsov N. A. 2

1 Higher Institute of Biochemistry, Gomel, Belarus; 2 Hypokinetic Physiology Laboratory, Athens, Greece


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Back­ground. ­Body hydra­tion homeo­stasis under­goes sig­nif­i­cant ­changes ­during a rig­orous bed ­rest (RBR), how­ever, ­little is ­known ­about the ­effect of ­acute bed ­rest (ABR) (­abrupt con­fine­ment to RBR) on ­body hydra­tion. We ­aimed to estab­lish ­body hydra­tion homeo­stasis ­during ABR and RBR.
­Methods. ­Studies ­were ­done ­during ­prebed ­rest (BR) ­period of 3 ­days and ­during 7 ­days ­period of ABR and RBR. ­Thirty ­healthy ­male indi­vid­uals ­aged, 24.6±5.7 ­years ­were ­chosen as sub­jects. ­They ­were ­divided ­into 3 ­groups: unre­stricted ambu­la­tory con­trol sub­jects (­UACS), ­acute bed ­rested sub­jects (­ABRS) and rig­orous bed ­rested sub­jects (­RBRS). ­Acute bed ­rested sub­jects con­fined ­abruptly to RBR, ­while ­they did not ­have any ­prior knowl­edge of the ­exact ­date and ­time ­when ­they ­would be ­asked to ­stay in bed. Rig­orous bed ­rested sub­jects sub­mitted to RBR on a pre­de­ter­mined ­date and ­time ­known to ­them ­right ­from the ­start of the ­study.
­Results. ­Fluid ­loss, uri­nary and ­plasma ­sodium (Na) and potas­sium (K), uri­nary and ­plasma osmo­lality, ­whole ­blood hem­a­tocrit (Hct) and hemo­globin (Hb), and ­total ­plasma pro­tein ­level ­increased sig­nif­i­cantly (p≤0.05), ­while extra­cel­lular ­volume (ECV), ­plasma ­volume (PV), red ­cell ­volume (RCV), ­blood ­volume (BV) and inter­sti­tial ­volume (IV) and ­fluid ­intake ­decreased sig­nif­i­cantly (p≤0.05) in ­ABRS and ­RBRS ­when com­pared ­with ­their pre-BR ­values and the ­values in ­UACS. How­ever, the meas­ured param­e­ters ­changed sig­nif­i­cantly (p≤0.05) ­more in ­ABRS ­than ­RBRS. ­Fluid ­loss, ­fluid ­intake, uri­nary and ­plasma Na and K, Hct, Hb, ­plasma pro­tein, uri­nary and ­plasma osmo­lality, ECV, PV, RCV, BV and IV ­change insig­nif­i­cantly (>0.05) in ­UACS ­when com­pared ­with ­their pre-BR ­values.
Con­clu­sions. It was con­cluded, ­that the ­more ­abruptly mus­cular ­activity is ­restricted the ­greater dehy­dra­tion of the ­body ­there is, and prob­ably in indi­vid­uals ­whose mus­cular ­activity is ­abruptly ter­mi­nated.

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