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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2002 February;161(1):7-18
Intercompartmental, plasma and urinary biochemical changes in healthy subjects during acute and rigorous bed rest and ambulation
Zorbas Y. G. 1, Yarullin V. L. 1, Denogratov S. D. 2, Kuznetsov N. A. 2
1 Higher Institute of Biochemistry, Gomel, Belarus;
2 Hypokinetic Physiology Laboratory, Athens, Greece
Background. Body hydration homeostasis undergoes significant changes during a rigorous bed rest (RBR), however, little is known about the effect of acute bed rest (ABR) (abrupt confinement to RBR) on body hydration. We aimed to establish body hydration homeostasis during ABR and RBR.
Methods. Studies were done during prebed rest (BR) period of 3 days and during 7 days period of ABR and RBR. Thirty healthy male individuals aged, 24.6±5.7 years were chosen as subjects. They were divided into 3 groups: unrestricted ambulatory control subjects (UACS), acute bed rested subjects (ABRS) and rigorous bed rested subjects (RBRS). Acute bed rested subjects confined abruptly to RBR, while they did not have any prior knowledge of the exact date and time when they would be asked to stay in bed. Rigorous bed rested subjects submitted to RBR on a predetermined date and time known to them right from the start of the study.
Results. Fluid loss, urinary and plasma sodium (Na) and potassium (K), urinary and plasma osmolality, whole blood hematocrit (Hct) and hemoglobin (Hb), and total plasma protein level increased significantly (p≤0.05), while extracellular volume (ECV), plasma volume (PV), red cell volume (RCV), blood volume (BV) and interstitial volume (IV) and fluid intake decreased significantly (p≤0.05) in ABRS and RBRS when compared with their pre-BR values and the values in UACS. However, the measured parameters changed significantly (p≤0.05) more in ABRS than RBRS. Fluid loss, fluid intake, urinary and plasma Na and K, Hct, Hb, plasma protein, urinary and plasma osmolality, ECV, PV, RCV, BV and IV change insignificantly (>0.05) in UACS when compared with their pre-BR values.
Conclusions. It was concluded, that the more abruptly muscular activity is restricted the greater dehydration of the body there is, and probably in individuals whose muscular activity is abruptly terminated.