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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2001 April;160(2):87-92
Correlation between ultrasonographic and histological endometrial findings during hormone replacement therapy
Camilli A., Camilli F. M., Di Benedetto L.
Università degli Studi di Roma «La Sapienza» - Roma, II Istituto di Clinica Ostetrica e Ginecologica
Background. Growing diffusion of HRT for menopausal symptom management induces to monitor its effects with simple, repeatable and painless methods. Transvaginal ultrasonography appears as the first step to monitor endometrial effects of HRT. Our purpose is to evaluate the correlation between ultrasonographic and histological endometrial findings during hormone replacement therapy (HRT) with trans-dermal estradiol and oral progestogen.
Methods. Forty healthy menopausal women without contraindications to HRT, underwent transvaginal ultrasonography and endometrial biopsy with normal findings. They underwent cyclic HRT with transdermal estradiol and oral progestogen for twelve months (estradiol for twenty-one days and progestogen for twelve days) and again underwent transvaginal ultrasonography (during pause week) and endometrial biopsy (during the third week of therapy). Basal and post therapy findings were evaluated with Student “t” test.
Results. One patient had endometrial thickness more than 5 mm and endometrial biopsy showed hyperplasia; thirthy-nine patients had endometrial thickness less than 5 mm and endometrial biopsy showed secretive endometrium. Difference between endometrial thick-ness was not statistically significant.
Conclusions. Endometrial thickness measured by transvaginal ultrasonography strongly correlates with histologic findings during HRT. Periodical transvaginal ultrasonography is a good tool for monitoring women treated with HRT.