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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2000 December;159(6):231-5
Clinical and epidemiological study of pharyngotonsillitis infections, caused by β-haemolytic Streptococcus of group A, in the pediatric population of Molfetta and Giovinazzo (Southern Italy)
Balducci O. 1, De Laurentiis L. 1, Facchini I. 1, Spadavecchia M. 1, Spano M. 1, Zanzarella C. 1, Lorusso L. 2, Portoghese A. 2, Pranzo C. 2, Traetta G. 2, Mezzina G. 3, Grasso G. 4, Mezzina M. 4
1 AUSL BA/2 - Molfetta;
2 AUSL BA/2 - Giovinazzo;
3 Ospedale Civile di Molfetta, Laboratorio Centrale d’Analisi;
4 Ufficio d’Igiene - Giovinazzo
Aims. Acute pharayngotonsillitis is one of the most common infections of the respiratory tract and 95% of cases of bacterial origin are caused by β-haemolytic Streptococcus of group A (SBEGA). In order to face a pathology with such a wide-ranging social impact, we found it necessary to use common strategies.
Methods. In this open study 122 patients were enrolled, aged 3-14 years, suffering from acute pharyngitis or pharyngotonsillitis with a clinical score according to modified Breese greater than 23. The patients were given antibiotic therapy in the form of suspension (amoxycillin-clavulanic acid, cefaclor, rokitamycin). The follow-up examination was carried out between 7 and 10 days after the end of therapy. In order to evaluate recovery, the clinical score of modified Breese and the positivity of pharyngeal swab for SBEGA and Staphylococcus aureus were considered. Antibiograms were carried out for all positive swabs.
Results. Clinical recovery was achieved in 100% of cases with amoxycillin-clavulanic acid and with rokitamycin. The best results as regards antibiograms were also found with amoxycillin-clavulanic acid and with rokitamycin.
Conclusions. In the treatment of pharyngotonsillitis it is necessary act early. In the area of antibiotic treatment amoxycillin-clavulanic acid and rokitamycin allow treatment of these young patients achieving successful clinical recovery. It is desirable to obtain responses to cultures and to antibiograms as quickly as possible in order to choose a therapy which is not only rational, but also increasingly specific.