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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2000 December;159(6):207-8
APC-resistence phenotype in the upper Aniene Valley, Lazio, Italy. Prevalence in a population of young women
Raffa S., Monaldo M.
ASL RM/G - Subiaco (Roma), Ospedale «A. Angelucci», Servizio di Patologia Clinica
Background. The aim of this study has been to evaluate the prevalence of APC-resistance phenotype in a community of the upper Aniene Valley, geographic area of eastern Lazio region, Italy.
Methods. The Activated protein C (APC)-resistance phenotype was searched in 183 women aged <40, included between 305 consecutive asymptomatic outpatient subjects, all resident in the upper Aniene Valley, examined during for a coagulative screening for inherited thrombophilia. The assessment of APC-r was carried out using a commercially available plasma-based method (FV aPTT method).
Results. The APC-resistance phenotype was found in five of the 183 young women (2.73%) and in ten of the 305 overall subjects (3.27%).
Conclusions. These percentages of prevalence are in agreement with the distribution of the Leiden mutation in the Italian general population and confirm a large diffusion of this defect also in our community.