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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2000 October;159(5):155-7
Endometrial histological findings dur-ing Hormone Replacement Therapy (HRT)
Di Benedetto L., Camilli A., Camilli F. M.
Università degli Studi «La Sapienza» - Roma, II Istituto di Clinica Ostetrica e Ginecologica
Background. The increasingly widespread use of HRT calls for careful monitoring of its effects on the endometrium. The aim of this study was to evaluate the presence of any endometrial histological aspects typical of HRT protocols using different types of progestin (oral administration) and differing structural characteristics of the transdermal system used to administer estradiol.
Methods. Thirty-nine menopausal patients without contraindications for HRT underwent endometrial histological analysis before starting sequential cyclical treatment using oral progestin (MAP, dydrogesterone or nomegestrol at the doses recommended in the Literature) and transdermal estradiol (reservoir system containing alcohol or matrix system). Twelve months after the start of treatment, control tests were performed during the third week of treatment (endometrial histological analysis).
Results. In all patients, histological analysis confirmed endometrial secretion in line with the phase of treatment.
Conclusions. All the protocols used were found to be safe for the endometrium, as is confirmed by its secretory transformation; no typical histological characteristics were therefore associated with each of the different treatment protocols examined.