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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2000 August;159(4):125-7
Hemostatic disorders in different stages of peripheral vascular disease
Trifiletti A., Scamardi R., Pizzoleo M. A., Attinà A., Sottilotta G., Barbera N.
Department of Internal Medicine, University of Messina
Background. Hemostatic disorders occur in the clinical history of peripheral occlusive arterial disease (POAD). The aims of this study were to confirm these hemostatic changes and to identify whether particular stages of POAD were more likely to show these disorders than others.
Methods. In 68 non-diabetic patients with obliterative arteriopathies of the lower limbs, in 41 age-matched volunteers and in 14 patients with acute pneumonia, thrombomodulin (TM), beta-thromboglobulin (β-TG), D-dimer (DD), plasminogen activator-inhibitor (PAI-1), prothrombin fragment 1+2 (F1+2) and fibrinopeptide A (FPA) were evaluated.
Results. The observed values show a significant increase, in stage II patients, of TM, β-TG and DD plasma levels. The stage III patients also show PAI-1 and F1+2 higher than the controls. All the parameters were found to be significantly higher in stage IV patients.
Conclusions. These data confirm that in vasculopathic patients, endothelium damage, platelet activation, impaired fibrinolytic potential and increase of fibrin turn-over gradually occur and may play an important role in the development of the thrombotic lesions.