Home > Journals > Gazzetta Medica Italiana Archivio per le Scienze Mediche > Past Issues > Gazzetta Medica Italiana Archivio per le Scienze Mediche 2000 August;159(4) > Gazzetta Medica Italiana Archivio per le Scienze Mediche 2000 August;159(4):125-7

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE

A Journal on Internal Medicine and Pharmacology


Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index

 

ORIGINAL ARTICLES  


Gazzetta Medica Italiana Archivio per le Scienze Mediche 2000 August;159(4):125-7

Copyright © 2000 EDIZIONI MINERVA MEDICA

language: English

Hemostatic disorders in different stages of peripheral vascular disease

Trifiletti A., Scamardi R., Pizzoleo M. A., Attinà A., Sottilotta G., Barbera N.

Department of Internal Medicine, University of Messina


PDF  


Background. Hemostatic dis­or­ders oc­cur in the clin­i­cal his­to­ry of pe­riph­er­al oc­clu­sive ar­te­ri­al dis­ease (­POAD). The ­aims of ­this ­study ­were to con­firm ­these he­mo­stat­ic chang­es and to iden­ti­fy wheth­er par­tic­u­lar stag­es of ­POAD ­were ­more like­ly to ­show ­these dis­or­ders ­than oth­ers.
Methods. In 68 non-di­a­bet­ic pa­tients ­with oblit­er­a­tive ar­ter­i­op­a­thies of the low­er ­limbs, in 41 age-ma­tched vol­un­teers and in 14 pa­tients ­with ­acute pneu­mo­nia, throm­bo­mod­u­lin (TM), be­ta-throm­bo­glob­u­lin (β-TG), D-dim­er (DD), plas­mi­no­gen ac­ti­va­tor-in­hib­i­tor (PAI-1), pro­throm­bin frag­ment 1+2 (F1+2) and fi­brin­o­pep­tide A (FPA) ­were eval­u­at­ed.
Results. The ob­served val­ues ­show a sig­nif­i­cant in­crease, in ­stage II pa­tients, of TM, β-TG and DD plas­ma lev­els. The ­stage III pa­tients al­so ­show PAI-1 and F1+2 high­er ­than the con­trols. All the pa­ram­e­ters ­were ­found to be sig­nif­i­cant­ly high­er in ­stage IV pa­tients.
Conclusions. These ­data con­firm ­that in vas­cu­lo­path­ic pa­tients, en­do­the­li­um dam­age, plate­let ac­ti­va­tion, im­paired fi­brin­o­lyt­ic po­ten­tial and in­crease of fi­brin ­turn-­over grad­u­al­ly oc­cur and may ­play an im­por­tant ­role in the de­vel­op­ment of the throm­bot­ic le­sions.

top of page

Publication History

Cite this article as

Corresponding author e-mail