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Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Online ISSN 1827-1812
Rampello L. 1, Raffaele R. 1, Vecchio I. 1, Pistone G. 2, Brunetto M. B. 1, Malaguarnera M. 2
1 Institute of Neurological Sciences, University of Catania;
2 Istitute of Internal Medicine and Geriatrics, University of Catania
We report hypotensive effects of thioridazine, a neuroleptic drug, used in the treatment of behavioural changes after traumatic brain injury, in the absence of cardiovascular disease, in two elderly patients during motor rehabilitation. The patients showed a decrease of anxiety and agitation after thioridazine administration dose of 25 mg/day, but they developed hypotensive crises without cardiovascular diseases. After suspension, patients became normotensive. This datum suggests that the alpha-receptor tropism of neuroleptics and their effects on arterial pressure make it difficult to treat elderly patients after brain injury, without cardiovascular disease.