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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE

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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2000 April;159(2):41-52

language: Italian

Circadian ­rhythm of sal­i­vary se­cre­to­ry IgA and in­ver­sion of ­sleep-­wake cy­cle and ­rest/ac­tiv­ity cy­cle

Rosaschino F. 1, Cisarri G. 1, Maggioni C. 2, Ferla R. 1, Patrini F. 1, Torre R. 1, Galliera M. 3

1 Università degli Studi - Milano, Istituti Clinici di Perfezionamento, Istituto di Pediatria, Cattedra di Clinica Pediatrica;
2 Università degli Studi - Milano, Istituti Clinici di Perfezionamento, Istituto di Ostetricia e Ginecologia, I Clinica;
3 Università degli Studi - Milano, Istituti Clinici di Perfezionamento, Istituto di Chirurgia Generale e Chirurgia dell’Apparato Digerente, Cattedra di Chirurgia Generale


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Background. It has ­been ob­served in our pre­vi­ous stud­ies ­that the se­cre­tion of the sal­i­vary s-IgA fol­lows a cir­ca­dian ­rhythm, and ­that the ac­ro­phase oc­curs in the ­first ­hours of the morn­ing. The aim of ­this in­ves­ti­ga­tion is to ver­i­fy if the pa­ram­e­ters of the ­rhythm are mod­i­fied by the va­ri­a­tions of two syn­chron­iz­ers, rep­re­sent­ed by the ­sleep/­wake cy­cle and by ­rest/ac­tiv­ity cy­cle.
Methods. Two ­healthy sub­jects ­have been stud­ied for 9 con­sec­u­tive ­days, di­vid­ed into ­three ­equal ex­peri­men­tal pe­ri­ods: in the I pe­ri­od (1st-3rd day) nor­mal ­style of ­live; in the II pe­ri­od (4th-6th day) in­ver­sion of the ­sleep/ wake cy­cle and ­rest/ac­tiv­ity cy­cle; in the III pe­ri­od (7th-9th day) nor­mal ­style of ­life ­again. Samples of sa­li­va ­have ­been tak­en eve­ry two ­hours (from 00.00 a.m. of the ­first day to 12.00 p.m. of the 9th day) and sal­i­vary s-IgA ­have ­been ti­trat­ed by the RID tech­nique. The se­ries of ­each day has ­been an­a­lyzed by the “sin­gle co­si­nor” in order to detect a significant circadian rhythm. Significative dif­fer­enc­es ­among ­three pe­ri­ods ­have ­been eval­u­at­ed by the one-way var­i­ance meth­od (p<0.05).
Results. Results ­show ­that in the II pe­ri­od the ac­ro­phase of the cy­cle is pro­gres­sive­ly de­layed in re­spect to the I pe­ri­od, un­til it co­in­cides ­with the ­last phas­es of ­sleep. In the III pe­ri­od the ac­ro­phase ­comes pro­gres­sive­ly ­back to its nor­mal oc­cu­rrence.
Conclusions. The in­ver­sion of the ­sleep/­wake cy­cle and of the ­rest/ac­tiv­ity cy­cle ­shifts the ac­ro­phase but ­does not re­set the ­rhythm. There is a ­strong cor­re­la­tion ­between the ac­ro­phase of the cir­ca­dian ­rhythm of sal­i­vary s-IgA and the ­last phas­es of ­sleep.

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