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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2000 April;159(2):41-52
Circadian rhythm of salivary secretory IgA and inversion of sleep-wake cycle and rest/activity cycle
Rosaschino F. 1, Cisarri G. 1, Maggioni C. 2, Ferla R. 1, Patrini F. 1, Torre R. 1, Galliera M. 3
1 Università degli Studi - Milano, Istituti Clinici di Perfezionamento, Istituto di Pediatria, Cattedra di Clinica Pediatrica;
2 Università degli Studi - Milano, Istituti Clinici di Perfezionamento, Istituto di Ostetricia e Ginecologia, I Clinica;
3 Università degli Studi - Milano, Istituti Clinici di Perfezionamento, Istituto di Chirurgia Generale e Chirurgia dell’Apparato Digerente, Cattedra di Chirurgia Generale
Background. It has been observed in our previous studies that the secretion of the salivary s-IgA follows a circadian rhythm, and that the acrophase occurs in the first hours of the morning. The aim of this investigation is to verify if the parameters of the rhythm are modified by the variations of two synchronizers, represented by the sleep/wake cycle and by rest/activity cycle.
Methods. Two healthy subjects have been studied for 9 consecutive days, divided into three equal experimental periods: in the I period (1st-3rd day) normal style of live; in the II period (4th-6th day) inversion of the sleep/ wake cycle and rest/activity cycle; in the III period (7th-9th day) normal style of life again. Samples of saliva have been taken every two hours (from 00.00 a.m. of the first day to 12.00 p.m. of the 9th day) and salivary s-IgA have been titrated by the RID technique. The series of each day has been analyzed by the “single cosinor” in order to detect a significant circadian rhythm. Significative differences among three periods have been evaluated by the one-way variance method (p<0.05).
Results. Results show that in the II period the acrophase of the cycle is progressively delayed in respect to the I period, until it coincides with the last phases of sleep. In the III period the acrophase comes progressively back to its normal occurrence.
Conclusions. The inversion of the sleep/wake cycle and of the rest/activity cycle shifts the acrophase but does not reset the rhythm. There is a strong correlation between the acrophase of the circadian rhythm of salivary s-IgA and the last phases of sleep.