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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE

A Journal on Internal Medicine and Pharmacology


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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2000 February;159(1):29-34

language: Italian

Microbiological assessment of microbicide and microbiostatic activity of phenoxyethanol

Minerva A.

Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione - Caserta, Immunoematologia e Servizio Trasfusionale


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A series of tests were carried out to assess the sensitivity of the main pathogenic micro-organisms to phenoxyethanol, in terms of both bactericide and bacteriostatic activity. The results of these tests show that phenoxyethanol is active in many of the pathogenic micro-organisms responsible for infections on burnt skin (e.g. Pseudomonas aeruginosa), skin wounds and bedsores. Moreover, the proximity of MIC and MIB values suggests that the compound probably acts on the cell membrane, altering permeability and compromising the structural integrity of the micro-organism. Compounds with a similar mechanism of action have a low probability of determining the onset of resistant micro-organisms, thus confirming the observation that phenoxyethanol activity is —both in quantitative and qualitative terms— broadly comparable to that observed several years ago.

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