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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 1999 October;158(5):169-73
Toxoplasmosis and urticaria
Barbosa Vosgerau J. C.
Dermalogist, Centro Municipal de Especialidades, Secretary of Health from Ponta Grossa (Brasil)
Chronic urticaria severity may be linked not only to severe pruritus but also to lifethreatening conditions, as Quinck’s edema or anaphylactic shock. There often is too poor a response to anti-histaminics or corticosteroids. Even these medicines can trigger urticaria or anaphylactic shock. Chronic toxoplasmosis is rarely remembered in patiens with urticaria. Toxoplasmosis symptoms are non-specific. Four patients are reported with severe chronic urticaria, unresponsive to the usual measures, long-standing for between 2-42 years, and toxoplasmosis that had anaphylactic shock to I.V. hydrocortisone, Quinck’s edema, lip edema, asthma, nausea, headache, arthritis/arthralgia, urinary infection, heart disorders, that were treated with specific toxoplasmosis medicines (roxithromycin, dapsone, pyrimethamine) and there was remission of urticaria and these others complaints. It is postulated that severe urticaria may be just a visible consequence of the cytokine storm triggered by Toxoplasma in the host and certainly IFN-γ and TNF-α have a central role in the pathophysiology of this skin disease beyond the other reported disorders.