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A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 1999 August;158(4):121-6
Osteoporosis, cardiovascular and hematologic disorders, a chronic toxoplasmosis triad and thalidomide
Barbosa Vosgerau J. C.
Centro Municipal de Especialidades, Secretariat of Health from Ponta Grossa
Osteoporosis became a nowadays concern for women, however it is not related just to menopause. Osteoporosis also occurs in males, young people or associated to several diseases. Chronic toxoplasmosis may affect any organ, even joints/bone tissues. It is reported 3 patients, 2 males and 1 female with osteoporosis that had severe joints/bone pain unresponsive to corticosteroids, antiinflamatoires, calcium, calcitonine that remitted or had a marked improvement with specific toxoplasmosis medicines and particularly when these drugs were associated to thalidomide 6.5 g/day. The osteoarticular pain in these patients was associated to cardiovascular and hematological disorders as hypertension/hypotension, severe congestive heart failure and arrhythmias, septic shock hypercholesterolemia/hypocholesterolemia, hypertriglyceridemia, aorta calcification, chronic anemia, eosinophilia, basophilia, leukocytosis, neutropenia, neutrofilia, thrombocytosis unresponsives to ususal measures. The joints/bone pain improvement was related to cardiovascular and hematologic improvement as well as osteoarticular complains deterioration was related to cardiovascular and hematological deterioration. It is postulated that IFN-γ has a central role in the toxoplasmosis pathophysiology and that these disorders are related to IL-1, IL-2, IFN-γ, TNF-α and IFN-α host intoxication triggered by toxoplasms. It seems that these osteoarticular, cardiovascular and hematologic disorders are not different diseases but just the same response in different organs to the same stimulus- host high levels of cytokines triggered by intracellular pathogens as toxoplasma.