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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE

A Journal on Internal Medicine and Pharmacology


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Gazzetta Medica Italiana Archivio per le Scienze Mediche 1999 April;158(2):55-7

language: Italian

Endocarditis due to brucellosis in patient with Marfan’s syndrome. A case report

Terra L. 1, Pellicanò S. 1, Bertuccio N. S. 2, Calzone R. 3, Dattola O. L. 1, Mandica D. 3, Seminara V. 2

1 Regione Calabria ASL n. 5 - Ospedale «S. Giovanni di Dio» - Crotone, Divisione di Malattie Infettive;
2 ASL 8 Ospedale Civile «G. Jazzolino» - Vibo Valentia, Divisione di Malattie Infettive;
3 egione Calabria ASL n. 5 - Ospedale «S. Giovanni di Dio» - Crotone, Dietista


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Marfan’s syndrome is a rare heritable disease of the connective tissue with an autosomial dominant inheritance caused by mutations in a single fibrillin gene on chromosome 15. It’s characterized by skeletal, ocular and cardiovascular manifestations such as mitral insufficiency due to prolapse, aortic dilatation or insufficiency, tricuspid valve insufficiency with or without prolapse. Cystic necrosis of the middle tunic in the aortic valve is observed with possible valvular rupture or formation of aneurysms. A bacterial endocarditis can develop on cardiovascular lesions. A case of endocarditis due to brucellosis in a patient with Marfan’s syndrome is described. The pathogenesis of alterations of this rare disease is underlined and the authors hypothesize that endocardic alterations are caused by brucella’s infection on the endothelium already damaged by hemodynamic factors.

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