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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 1999 February;158(1):27-36
Therapy of respiratory tract inflammations: a nimesulide-flunisolide comparison. Preliminary results
Brivio G. 1, Boscolo M. A. 1, Biraghi M. 2
1 Ospedale Generale Provinciale «San Leopoldo Mandic» - Merate (Como), Divisione di Medicina;
2 Valeas SpA - Milano, Direzione Medica
Background. The trial set out to make an assessment and a comparison in terms of efficacy and side effects of flunisolide in aerosol form and nimesulide administered orally in two groups of patients sufferring from inflammation respectively of the upper respiratory tract (Group A) and of the lower respiratory tract (Group B).
Methods. Both groups were divided into two sub-groups and in each group (A and B) one such sub-group was treated with flunisolide and the other with nimesulide. The evaluation criteria adopted were: the recurrent objective and subjective clinical parameters of the pathology examined (upper or lower respiratory tract) in all patients suffering from inflammation of the lower respiratory tract (Group B), any side effects noted during the treatments. The trial included 20 patients in Group A (10 treated with flunisolide and 10 with nimesulide) and 20 patients in Group B (10 with flunisolide and 10 with nimesulide).
Results. Benefits from both treatments were experienced by the patients with inflammation of the upper respiratory tract (Group A) without any significant differences being recorded between those patients treated with flunisolide and the ones treated with nimesulide. The case of patients with inflammation of the lower respiratory tract (Group B) the treatment with flunisolide proved to be more efficacious than that with nimesulide. In both groups there were less side effects among the patients treated with flunisolide then among those treated with nimesulide.
Conclusions. The trial shows that flunisolide is efficacious in the treatment of inflammation both of the upper and lower respiratory tract and that it produces less side effects than nimesulide.