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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
A Journal on Internal Medicine and Pharmacology
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 1998 June;157(3):79-83
Yuppies’s syndrome. The obscure disease of the twenty-first century?
DEA - Azienda Ospedaliera, S. Giovanni-Addolorata - Roma
Yuppies’s syndrome or chronic fatigue is a morbid picture characterized by a condition of disabling fatigue of uncertain etiology with endocrine and muscular immunologic aberration. Well-known from the Hippocratic period, for many years it has been called with several definitions. Unfortunately, the etiopathogenesis of this syndrome is still presenting many doubts, perplexity and uncertainties. In the last years several etiological theories have been suggested. The most important is the immunologic theory. In 1988 the United States Centers for disease control and prevention suggested to call it “chronic fatigue syndrome”. The clinical picture is characterized by: fever, fatigue, myalgia, neurologic symptoms presenting between 35 and 50 years of age and there is a preponderance of females working in towns. There are several therapies: diet, cognitive behaviour programme, antidepressants drugs. Most of the treatment which have been properly evaluated seem to be more or less ineffective. The long-term prognosis of patients with chronic fatigue syndrome has not been well studied, but it appears to be a disease of long-term duration with considerable morbidity but no mortality.