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Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index
Online ISSN 1827-1642
Hatanaka S. A. 1, Silva N. O. 1, Colombo B. S. 2, Correa C. G. 2, Alcaire B. P. 1, Coral M. H. 2, Schiavon L. L. 3, Narciso-Schiavon J. L. 3
1 Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil;
2 Department of Endocrinology, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil;
3 Department of Gastroenterology and Hepatology, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil
AIM: Metabolic syndrome and type 2 diabetes are associated with insulin resistance and hepatic steatosis, which are common causes of alanine aminotransferase (ALT) elevation. This study aims to identify variables associated with altered ALT in type 1 diabetic (DM1) subjects.
METHODS: A cross-sectional study conducted in the outpatient endocrinology clinic of a university hospital. Patients with DM1 were seen between December 2012 and September 2013; clinical variables were collected from medical records.
RESULTS: Fifty-six patients were included aged 27±10.1 years; 60.7% were men. The study subjects exhibited an average ALT of 36.7±10.3 U/L (median=35 U/L) and their average Body Mass Index (BMI) was 23.8±3.8 kg/m2. When comparing individuals with elevated ALT>35 U/L (N.=27) with those ALT≤35 U/L (N.=29), we found that individuals with ALT values > 35 U/L showed a higher proportion of men (77.8% vs. 44.8%, P=0.012) and a higher mean age (30.2±12.3 vs. 24.6±6.9 years, P=0.046). When new ALT reference values were applied (19 U/L for women and 30 U/L for men), five individuals had normal ALT values. Individuals with elevated ALT had higher BMI (24.3 vs. 20.9; P=0.036), fasting glucose (194.8±101.2 vs. 123.6±42.0 mg/dL; P=0.013) and higher HbA1c (9.9±2.8 vs. 7.8±0.7%; P <0.001) levels. In Pearson correlation analysis, ALT values correlated with HbA1c (r=0.285; P=0.033).
CONCLUSION: In patients with DM1, elevated ALT values are associated with BMI, fasting glucose and HbA1c.