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A Journal on Gastroenterology, Nutrition and Dietetics
Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index
Minerva Gastroenterologica e Dietologica 2015 September;61(3):137-43
Factors associated with elevated serum alanine aminotransferase in patients with type 1 diabetes mellitus
Hatanaka S. A. 1, Silva N. O. 1, Colombo B. S. 2, Correa C. G. 2, Alcaire B. P. 1, Coral M. H. 2, Schiavon L. L. 3, Narciso-Schiavon J. L. 3
1 Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil;
2 Department of Endocrinology, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil;
3 Department of Gastroenterology and Hepatology, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil
AIM: Metabolic syndrome and type 2 diabetes are associated with insulin resistance and hepatic steatosis, which are common causes of alanine aminotransferase (ALT) elevation. This study aims to identify variables associated with altered ALT in type 1 diabetic (DM1) subjects.
METHODS: A cross-sectional study conducted in the outpatient endocrinology clinic of a university hospital. Patients with DM1 were seen between December 2012 and September 2013; clinical variables were collected from medical records.
RESULTS: Fifty-six patients were included aged 27±10.1 years; 60.7% were men. The study subjects exhibited an average ALT of 36.7±10.3 U/L (median=35 U/L) and their average Body Mass Index (BMI) was 23.8±3.8 kg/m2. When comparing individuals with elevated ALT>35 U/L (N.=27) with those ALT≤35 U/L (N.=29), we found that individuals with ALT values > 35 U/L showed a higher proportion of men (77.8% vs. 44.8%, P=0.012) and a higher mean age (30.2±12.3 vs. 24.6±6.9 years, P=0.046). When new ALT reference values were applied (19 U/L for women and 30 U/L for men), five individuals had normal ALT values. Individuals with elevated ALT had higher BMI (24.3 vs. 20.9; P=0.036), fasting glucose (194.8±101.2 vs. 123.6±42.0 mg/dL; P=0.013) and higher HbA1c (9.9±2.8 vs. 7.8±0.7%; P <0.001) levels. In Pearson correlation analysis, ALT values correlated with HbA1c (r=0.285; P=0.033).
CONCLUSION: In patients with DM1, elevated ALT values are associated with BMI, fasting glucose and HbA1c.