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Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index
Online ISSN 1827-1642
CUTTING EDGE GASTROENTEROLOGY
Imam M. H. 1, Talwalkar J. A. 1, Lindor K. D. 2
1 Division of Gastroenterology and Hepatology Mayo Clinic, Cholestatic Liver Diseases Study Group, Rochester, MN, USA;
2 Office of Executive Vice Provost, Health Solutions, Arizona State University, Phoenix, AZ, USA
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown etiology despite advances in medical research that have focused on uncovering its pathogenesis. Recent developments in the diagnosis of PSC including technological advances in magnetic resonanace cholangiography and the recognition of distinct clinical subtypes have led to more frequent early detection and appropriate therapy when indicated. Continued work in the areas of identifying genetic predisposing factors and novel molecular therapeutic targets are expected to create new opportunities for treating patients suffering from this chronic illness. In this review we highlight recent advances in PSC pathogenesis, diagnosis and management.