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MINERVA GASTROENTEROLOGICA E DIETOLOGICA

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Minerva Gastroenterologica e Dietologica 2011 December;57(4):419-26

language: English

Nonalcoholic fatty liver disease: the concept and confusion

Sanal M. G. 1, 2

1 Institute of Liver and Biliary Sciences, New Delhi, India
2 Special Center for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India


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Nonalcoholic fatty liver disease (NAFLD) is generally considered as a disease associated with diabetes mellitus type 2. But on a closer evaluation we realize a host of confusion associated with this from the nomenclature, diagnosis to pathogenesis. The term refers to a spectrum ranging from steatosis to steatosis with inflammation (NASH) to cirrhosis in the absence of alcohol abuse. But in fact NAFLD is a vague term for a spectrum of diseases which differ not only in the clinical presentation but also in the etiology. NAFLD is loose to incorporate so many etiologies excluding alcoholism and few other “known” etiologies, presenting as fat in liver. Considering the diverse etiologies there is a need for personalized management in NAFLD, which at present is difficult. Currently fatty liver disease could be considered as an added Hepato-cardiovascular-renal and cancer risk factor rather than a specific diagnosis.

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