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MINERVA GASTROENTEROLOGICA E DIETOLOGICA
A Journal on Gastroenterology, Nutrition and Dietetics
Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index
Minerva Gastroenterologica e Dietologica 2010 December;56(4):389-96
The efficacy of policosanols in the treatment of associated hyperlipidemia in patients with non-alcoholic fatty liver disease
Musto D., Martorelli L., Russo M., Esposito G., Amato M. R., Esposito P., Riegler G. ✉
D.A.I. di Medicina Interna e Specialistica, Unità Operativa Complessa di Gastroenterologia e Endoscopia Digestiva, Seconda Università degli Studi di Napoli, Napoli, Italia
AIM: The purpose of this study was to evaluate the efficacy of policosanols in the treatment of associated hyperlipidemia in patients with non-alcoholic fatty liver disease (NAFLD).
METHODS: We conducted a retrospective study on 52 patients with NAFLD. Pretreatment patients’ data (total cholesterol, LDL cholesterol, triglycerides, ALT, and AST) were collected and analyzed. Furthermore, based on weight and height, we calculated the Body Mass Index (BMI) and, based on blood glucose and insulin levels, we estimated the Human Omeostatic Assesment Index (HOMA). After that, all patients were treated with a policosanols’ supplement (Frilipid®) and a hypocaloric balanced diet, and then followed over time with quarterly inspections. We collected and analyzed data on three subsequent quarterly monitoring during treatment.
RESULTS: The collected and analyzed data showed a significant reduction in total cholesterol, LDL cholesterol and HOMA index (P<0.002). It was also found a trend not statistically significant for a marked reduction in ALT, AST, triglycerides, and BMI.
CONCLUSION: The use of policosanols is shown effective in the treatment of associated hyperlipidemia and insulin resistance in patients with fatty liver disease.