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Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index
Online ISSN 1827-1642
Kouklakis G. 1, Moschos J. 1, Paikos D. 1, Tagarakis G. 2, Rouska E. 1, Mpoumponaris A. 1, Lyrantzopoulos N. 1, Molyvas E. 1, Minopoulos G. 1
1 Medical School, Democritus University of Thrace Alexandroupolis, Greece
2 Surgery Department Theageneion Hospital, Thessaloniki, Greece
There are several studies suggesting the paradoxical simultaneous presence of hypertensive lower oesophageal sphincter and gastroesophageal reflux disease. We present a case of a 22-year-old male patient who was examined in our outpatient clinic with oesophageal food bolus impaction during a meal, severe chest pain and drooling. Manometry revealed a hypertensive lower esophageal sphincter pressure (resting pressure 35 mmHg) and pHmetry revealed a DeMeester score >14.72 (43.27). Six months after therapy with lansoprazole, manometry revealed a normal lower oesophageal sphincter (resting pressure 14 mmHg) and the DeMeester score was <14.72 (5.89). The patient is now asymptomatic. This report is the only published case which exhibits the normalization of lower oesophageal pressure 6 months after gastroesophageal reflux disease management with lansoprazole, thus proving and establishing the above “paradox”.