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MINERVA GASTROENTEROLOGICA E DIETOLOGICA

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Minerva Gastroenterologica e Dietologica 2007 September;53(3):279-83

Copyright © 2007 EDIZIONI MINERVA MEDICA

language: English

Hepatocellular carcinoma complicating primary sclerosing cholangitis in Crohn’s disease. A case report

Demarchi B., Bresso F., Novero D., Palestro G., Sapone N., Pellicano R., Bonardi R., Smedile A., Rizzetto M., Astegiano M.

1 Department of Gastroenterology Molinette Hospital, Turin, Italy 2 Institutionen for Medicin Karolinska Institutet, Stockholm, Sweden 3 Department of Biomedical Sciences and Human Oncology University of Turin, Turin, Italy


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The prevalence of primary sclerosing cholangitis (PSC) in Crohn’s disease (CD) patients is up to 8.5%. Although cholangiocarcinoma may complicate long-standing PSC in one third of the cases if follow-up is extended long enough, hepatocellular carcinoma (HCC) is a rare complication of PSC. The concomitant presence of PSC, HCC and CD have been reported sporadically. We discuss here a case of association of these three conditions.

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