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MINERVA GASTROENTEROLOGICA E DIETOLOGICA
A Journal on Gastroenterology, Nutrition and Dietetics
Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index
Minerva Gastroenterologica e Dietologica 2006 March;52(1):97-105
Prognostic factors of primary biliary cirrhosis detected by health screening
Yoneyama K., Yamazaki M., Kogo M., Kiuchi Y., Shibata M., Imawari M.
1 Health Service Center, Showa University, Japan
2 Department of Pathophysiology Showa University School of Pharmaceutical Sciences, Japan
3 Department of Gastroenterology, Kanto Medical Center NTT EC, Japan
4 Second Department of Internal Medicine, Showa University School of Medicine, Japan
Aim. The liver cirrhosis is likely to differ in the Japanese and Western populations. Thus, we performed a retrospective cohort analysis by a review of clinical records to clarify prognostic factors after the onset of primary biliary cirrhosis (PBC) detected by health screening.
Methods. The subjects were 52 patients with PBC. Thirty-nine factors were evaluated concerning clinical data and extracted prognostic factors using the Cox proportional hazard model.
Results. The mean duration of the follow-up period was 5.1 years, during which 6 (11.5%) of the patients died. The cumulative survival rate after the onset of PBC was 93.4% after 5 year, and 67.8% after 10 years. Multivariate analysis indicated 2 factors, i.e. the body mass index (BMI), and IgG, as independent prognostic factors. Their hazard ratios were 0.399 (per 1 kg/m2 of BMI) and 1.282 (per 100 mg/dL of IgG). The prognostic index (PI) was calculated by the following formula using these 2 factors. PI = –0.919¥BMI+0.249¥IgG.
Conclusion. The prediction of the outcome using PI based on the 2 factors provides additional information for the determination of the therapeutic approach in PBC after health screening.