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Minerva Gastroenterologica e Dietologica 2005 June;51(2):187-92

language: English

Chronic anaemia and adhesion molecules in patients with liver cirrhosis. A preliminary report

Bruno C. M., Sciacca C., Cilio D., Bertino G., Marchese E., Politi G., Chinnice L., Pellicano R.


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Aim. The aim of our study was to investigate circulating levels of intercellular adhesion molecule-1 (sICAM-1) and vascular cellular adhesion molecule-1 (sVCAM-1) in cirrhotic patients, with and without chronic anaemia, to establish whether there was a relation- ship between inflammatory activity and anaemia.
Methods. We investigated 14 anaemic (mean hemoglobin value 10.65±1.06 g/dL) and 14 non anaemic (mean hemoglobin value 13.8±0.89 g/dL) subjects affected by virus C-related liver cirrhosis comparable for sex, age and degree of liver dysfunction such as expressed by Child-Pugh classification. Circulating sICAM-1 and sVCAM-1 were measured by EIA commercial kit (R&D System Co, Abington, UK) and mean± standard deviation values in two groups were compared by t-test and Kruskall-Wallis test.
Results. Mean±standard deviation sICAM-1 was 35.06±4.06 ng/mL in anaemic and 23.39± 6.1 ng/mL in non anaemic cirrhotic patients. Mean±standard deviation sVCAM-1 was 47.66±8.18 ng/mL in anaemic 31.77±6.08 ng/mL in non anaemic patients, respectively. Statistical analysis showed a significant difference between the two groups both in sICAM-1 (p=0.01) and sVCAM-1 (p=0.03) values.
Conclusions. Our study show that chronic anaemia, in liver cirrhosis, is associated to a greater increase of circulating adhesion molecules and suggests that inflammation may contribute to persistence of anaemic state, worsening the outcome of cirrhotic patients.

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