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Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index
Online ISSN 1827-1642
Bruno C. M., Sciacca C., Cilio D., Bertino G., Marchese E., Politi G., Chinnice L., Pellicano R.
Aim. The aim of our study was to investigate circulating levels of intercellular adhesion molecule-1 (sICAM-1) and vascular cellular adhesion molecule-1 (sVCAM-1) in cirrhotic patients, with and without chronic anaemia, to establish whether there was a relation- ship between inflammatory activity and anaemia.
Methods. We investigated 14 anaemic (mean hemoglobin value 10.65±1.06 g/dL) and 14 non anaemic (mean hemoglobin value 13.8±0.89 g/dL) subjects affected by virus C-related liver cirrhosis comparable for sex, age and degree of liver dysfunction such as expressed by Child-Pugh classification. Circulating sICAM-1 and sVCAM-1 were measured by EIA commercial kit (R&D System Co, Abington, UK) and mean± standard deviation values in two groups were compared by t-test and Kruskall-Wallis test.
Results. Mean±standard deviation sICAM-1 was 35.06±4.06 ng/mL in anaemic and 23.39± 6.1 ng/mL in non anaemic cirrhotic patients. Mean±standard deviation sVCAM-1 was 47.66±8.18 ng/mL in anaemic 31.77±6.08 ng/mL in non anaemic patients, respectively. Statistical analysis showed a significant difference between the two groups both in sICAM-1 (p=0.01) and sVCAM-1 (p=0.03) values.
Conclusions. Our study show that chronic anaemia, in liver cirrhosis, is associated to a greater increase of circulating adhesion molecules and suggests that inflammation may contribute to persistence of anaemic state, worsening the outcome of cirrhotic patients.