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MINERVA GASTROENTEROLOGICA E DIETOLOGICA
A Journal on Gastroenterology, Nutrition and Dietetics
Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index
OBESITY: NEW DIETOTHERAPEUTIC METHODS
Minerva Gastroenterologica e Dietologica 2001 December;47(4):205-8
Adipose tissue and cytokines
Trotti R., Cestaro B., Cazzola R., Ferrari E., Rondanelli M.
Adipose tissue is not simply a storage depot for excessed energy intake, it is also able to produce and release several substances with local (autocrine) and systemic (endocrine) actions. An up-to-date review of our knowledge in this area is given here. Several of the compounds deriving from adipose tissue have been shown to play a role in obesity-related health complications. The production of cytokines, such as Tumor Necrosis Factor-alpha (TNF-alpha), IL-6, and leptin, is implicated in the development of several disorders. Insulin resistance is one of the most clinically significant.