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MINERVA GASTROENTEROLOGICA E DIETOLOGICA

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Minerva Gastroenterologica e Dietologica 2001 December;47(4):187-94

language: Italian

The hypocaloric balanced diet therapy and the supplementation with antioxidant and w-3. What are the effects on oxidative balance and erythrocytes membrane fluidity status?

Cazzola R., Rondanelli M., Russo Volpe S., Barzaghi E., Ferrari E., Cestaro B.


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Background. To investigate the effects of a hypocaloric balanced diet therapy and a supplementation with antioxidant and w-3 polyunsaturated fatty acids on the oxidative balance and erythrocytes membrane fluidity status.
Methods. A randomised, double-blind, placebo-controlled study of the association between a hypocaloric balanced diet therapy and a supplementation with antioxidant and w-3 was done on 40 women with 25Results. The preliminary results of this study show that the weight loss, found in both groups investigated, determines a significant decrease of ROS. Furthermore, the association of the hypocaloric diet with antioxidant and w-3 polyunsaturated fatty acids caused a significant increase of both plasmatic antioxidant defences and erythrocytes membrane fluidity status.
Conclusions. The correlations found between the above parameters and the blood chemistry and anthropometrics variables suggest that the supplementation with antioxidant and w-3 polyunsaturated fatty acids could ameliorate the effects of hypocaloric diet on the obesity treatment and may give some clinical benefit through the decrease of the values of atherosclerosis risk factors.

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