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A Journal on Gastroenterology, Nutrition and Dietetics

Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index

Frequency: Quarterly

ISSN 1121-421X

Online ISSN 1827-1642


Minerva Gastroenterologica e Dietologica 1999 March;45(1):43-50


Gastroesophageal reflux disease. Pathogenesis, symptoms and complications

Cioffi U., Rosso L., De Simone M.

The onset of GERD depends on several factors leading to a prolonged exposition of the esophageal mucosa to inflammatory agents. Various mechanisms play a role in different patients, but generally, decreased LES tone and delayed esophageal clearance are the major causes. Although pyrosis and regurgitation are the most frequent complaints, the patient may have different symptoms or can be asymptomatic. The symptoms are not necessarily correlated with damaged mucosa. Recognized complications caused by reflux include esophagitis, stricture, hemorrhage, Barrett¹s epithelium and ulceration, aspiration and respiratory implications. The severity of complications may be an important element in predicting whether the patient can be successfully treated medically or surgically. The exact knowledge of the pathogenesis is mandatory for carrying out the most effective treatment.

language: English

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