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EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE

A Journal on Physical Medicine and Rehabilitation after Pathological Events


Official Journal of the Italian Society of Physical and Rehabilitation Medicine (SIMFER), European Society of Physical and Rehabilitation Medicine (ESPRM), European Union of Medical Specialists - Physical and Rehabilitation Medicine Section (UEMS-PRM), Mediterranean Forum of Physical and Rehabilitation Medicine (MFPRM), Hellenic Society of Physical and Rehabilitation Medicine (EEFIAP)
In association with International Society of Physical and Rehabilitation Medicine (ISPRM)
Indexed/Abstracted in: CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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European Journal of Physical and Rehabilitation Medicine 2017 Jul 10

DOI: 10.23736/S1973-9087.17.04533-6

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Can vitamin D deficiency influence muscle performance in post-menopausal women? A multicenter retrospective study

Giovanni IOLASCON 1 , Giulia LETIZIA MAURO 2, Pietro FIORE 3, Carlo CISARI 4, Maria Grazia BENEDETTI 5, Lorenzo PANELLA 6, Alessandro DE SIRE 1, Dario CALAFIORE 1, Antimo MORETTI 1, Francesca GIMIGLIANO 7

1 Department of Medical and Surgical Specialties and Dentistry, University of Campania “Luigi Vanvitelli”, Naples, Italy; 2 Department of Surgical, Oncologic and Stomatologic Disciplines, University of Palermo, Palermo, Italy; 3 Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy; 4 Department of Physical Medicine and Rehabilitation, University Hospital "Maggiore della Carità", Novara, Italy; 5 Physical Medicine and Rehabilitation Unit, Istituto Ortopedico Rizzoli, Bologna, Italy; 6 Department of Rehabilitation and Functional Recovery, Gaetano Pini Orthopedic Institute, Milan, Italy; 7 Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy


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BACKGROUND: The presence of the vitamin D receptor (VDR) has been recently demonstrated in human muscle supporting the theory of a role of vitamin D in the proliferation and differentiation of muscle cells. So far only few studies investigated the association between vitamin D and muscle performance in post-menopausal women.
AIM: To define the functional impact of vitamin D deficiency.
DESIGN: Multicenter retrospective study.
SETTING: Five Italian outpatient services of Physical and Rehabilitation Medicine (PRM).
POPULATION: Post-menopausal women.
METHODS: We divided the population in two groups based on the threshold of 30 ng/ml as cut-off to define sufficient and insufficient serum levels of 25-hydroxyvitamin D3 [25(OH)D3]. Outcome measures were: appendicular lean mass (ALM); ALM-to-BMI ratio (ALMBMI); total fat mass (FM); visceral adipose tissue (VAT); Hand Grip Strength (HGS); Knee Isometric Extension Strength (KES); Short Physical Performance Battery (SPPB); 4-meter gait speed (4MGS).
RESULTS: We analyzed the data records of 401 post-menopausal women (mean age 66.93 ± 8.47 years): 203 with hypovitaminosis D (mean age 66.81 ± 8.11 years) and 198 with normal levels of 25(OH)D3 (mean age 67.04 ± 8.84 years). The analysis showed a significant differences between the two groups in terms of: ALMBMI (0.002), FM (p 0.001), VAT mass (0.010), VAT volume (p =0.006), HGS (p<0.001), KES (p<0.001), SPPB score (p <0.001), percentage of people with a 4MGS≤ 0.8 m/s (p<0.001). Furthermore, there were significant correlations (p<0.001) between serum levels of 25(OH)D3 and HGS (r=0.323), KES (r=0.510), and SPPB sit to stand (r=-0.362) and walking sub-scores (r=-0.312).
CONCLUSION: This multicenter study demonstrated that post-menopausal women with vitamin D deficiency had a significant reduction of appendicular muscle strength and physical performance.
CLINICAL REHABILITATION IMPACT: This study reported the frequency of hypovitaminosis D in postmenopausal women and its influence on the reduction of muscle mass, strength, and physical performance in a typical population referring to the physiatrist for musculoskeletal disorders.


KEY WORDS: Vitamin D - Vitamin D deficiency - Sarcopenia - Muscle strength - Muscle performance

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Publication History

Article first published online: July 10, 2017
Manuscript accepted: July 7, 2017
Manuscript revised: March 21, 2017
Manuscript received: October 10, 2016

Cite this article as

Iolascon G, Letizia Mauro G, Fiore P, Cisari C, Benedetti MG, Panella L, et al. Can vitamin D deficiency influence muscle performance in post-menopausal women? A multicenter retrospective study. Eur J Phys Rehabil Med 2017 Jul 10. DOI: 10.23736/S1973-9087.17.04533-6

Corresponding author e-mail

giovanni.iolascon@gmail.com