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EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
A Journal on Physical Medicine and Rehabilitation after Pathological Events
Official Journal of the , , , ,
In association with
Indexed/Abstracted in: CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,063
European Journal of Physical and Rehabilitation Medicine 2013 June;49(3):319-29
Effects of a home-based walking training program on cardiorespiratory fitness in breast cancer patients receiving adjuvant chemotherapy: a pilot study
Vincent F. 1, 2, Labourey J.-L. 3, Leobon S. 3, Antonini M.-T. 1, Lavau-Denes S. 2, 3, Tubiana-Mathieu N. 2, 3 ✉
1 CHU Limoges, Dupuytren Hospital, Service of Physiological Functional Investigation, Limoges, F-87042, France;
2 Limoges University, Faculty of Medicine, EA3842, Limoges, F-87000, France;
3 CHU Limoges, Service of Medical Oncology, Limoges, F-87042, France
Background: Breast cancer treatment is associated with a decline in measured cardiorespiratory fitness and increased fatigue. There is accumulating evidence that exercise training during adjuvant chemotherapy may contribute to prevent these changes. Additional studies are needed to explore the effectiveness of home-based walking interventions among this population.
Aim: The aim of this study was to investigate the effects of a 12-week adapted home-based walking training program (WTP) on clinical rehabilitation in breast cancer patients receiving adjuvant chemotherapy.
Design: This was a pilot study using a single-group design.
Setting: Unit Department of Physiology and Medical Oncology, Limoges University Hospital, France.
Population: Thirty-nine outpatients predominantly with stage II breast cancer.
Methods: Participants performed 3 home ambulatory aerobic walking sessions per week at 50-60% of their maximum heart rate for 12 weeks. Functional capacity was assessed with an incremental cardiopulmonary exercise test during which peak oxygen consumption (VO2peak) was measured. A six-minute walking test (6MWT) was performed to evaluate physical function. The revised Piper Fatigue Scale (PFS-R) was used to measure self-reported fatigue.
Results: Thirty-four patients (87%) completed all study procedures. Per Protocol (PP) analysis indicated that VO2peak recorded both before and after a 12-week adapted home-based WTP increased significantly by 2.21 mL.kg-1.min-1 (P=0.008) and 6MWT distance increased significantly by 42m (P=0.04). PFS-R score increased by 0.4 points, but not significantly.
Conclusion: In breast cancer patients receiving adjuvant chemotherapy, home-based WTP is feasible and associated with significant improvements in VO2peak, with no significant effect on fatigue score. Larger randomized trials are necessary to confirm these findings.