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ESPERIENZE DERMATOLOGICHE

A Journal on Dermatology


Journal of Istituto Dermatologico San Gallicano
Official Journal of the Associazione Dermatologi Ospedalieri Italiani - A.D.O.I.
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Esperienze Dermatologiche 2016 June;18(2):80-4

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: Italian

Effectiveness and tolerability of a cream containing hyaluronic acid, sodium salt 2 mg/g and argentic sulphadiazine 10 mg/g in acute radiodermatitis treatment

Gabriella FABBROCINI 1, Giuseppe RUSSO 1, Martina FONTANELLA 1, Maria C. ROMANO 2, Norma CAMELI 3, Maria MARIANO 3, Mario DELFINO 1, Gaia DE FATA SALVATORES 1, Luigia PANARIELLO 1

1 Sezione di Dermatologia, Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli Federico II, Napoli, Italia; 2 Azienda Ospedaliera San Camillo-Forlanini, Roma, Italia; 3 Istituto Dermatologico San Gallicano, Istituti Fisioterapici Ospedalieri (IFO), Roma, Italia


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BACKGROUND: Skin toxicity is one of the main side effects caused by radiotherapy. The radiation treatment, infact, can cause xerosis, ichthyosis, rugosity, precancerous and cancerous lesions. The aim of our study is to evaluate the effectiveness and tolerability of a cream containing hyaluronic acid sodium salt 2 mg/g and argentic sulphadiazine 10 mg/g (Connettivina plus) in acute radiodermatitis treatment.
METHODS: Three dermatological center were involved (20 patients recruited from the Section of Dermatology of University of Naples Federico II, 10 patients from San Gallicano Dermatological Institute in Rome and 10 from San Camillo-Forlanini Hospital). Patients were divided in two groups: group A composed by 20 patients, used the cream containing hyaluronic acid sodium salt 2 mg/g and argentic sulphadiazine; group B composed by 20 patients used a cream commonly recommended by dermatologists containing argan oil.
RESULTS. Paired t-test was performed. Patients of group A demostred a significant higher improvement respect group B (P<0.01). The cream containing hyaluronic acid sodium salt 2 mg/g and argentic sulphadiazine induced a reduction of erythema, assessed by clinical images; a reduction of TEWL, assessed by Tewameter®; an improvement of skin hydration assessed by both corneometry and D-squame®; an excellent tolerability, evaluated through a specific questionnaire.
CONCLUSIONS: The cream containing hyaluronic acid sodium salt 2 mg/g and argentic sulphadiazine 10 mg/g is a useful therapeutic tool that can improve and prevent side effects caused by radiotherapy.

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