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A Journal on Dermatology
Esperienze Dermatologiche 2016 June;18(2):70-5
Effectiveness of a multi-component lotion in the control of hair loss
Giada MARAMALDI 1, Luca GIACOMELLI 2, Martino MENEGHIN 1, Roberto EGGENHOFFNER 2, Stefano TOGNI 1
1 Indena S.p.A., Milan, Italy; 2 Department of Surgical Sciences and Integrated Diagnostics, School of Medicine, Genoa University, Genoa, Italy
BACKGROUND: In order to find effective herbal compound for the treatment of hair loss, a multicomponent lotion (esculin 1%, ximenynic acid 0.5%, lauric acid 0.2% as conditioning and protective agent) has been tested in subjects suffering from alopecia.
METHODS: Subjects with androgenic alopecia of stage II-III Hamilton Scale and Stage I-II Ludwig scale were enrolled in this randomized, double-blind, parallel, vehicle-controlled study. The study comprised the following time periods: 90-day treatment; 30-day suspension and 45-day treatment (follow-up period). Hair density, parameters of hair bulb activity, miniaturised hair shaft and cutaneous circulation were evaluated at inclusion, during and after the 90-day treatment, at the beginning and at the end of the 45-day follow-up period.
RESULTS: In total, 20 subjects/group were enrolled. At the end of the three-month treatment, in the treated group there were significant improvements in trichogram findings: a significant increase of hair in anagen phase, and a significant decrease of hair in telogen and dystrophic anagen phases have been observed. Phototrichogram data showed no significant differences in hair density and a significant decrease in telogen phase hairs compared with placebo group. After the 30-day suspension, 13 subjects previously treated with the active lotion resumed the treatment for 45 days. Trichogram results showed an enduring positive effect of the previous treatment. The following 45-day treatment induced improvements in the percentage of anagen and telogen phase hairs and a favorable trend toward increased hair density. Moreover, the subjective evaluation of the efficacy and the cosmetic parameters of the tested lotion showed an overall positive effect.
CONCLUSIONS: The results obtained support the efficacy of this multi-component lotion in the control of hair loss.