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CURRENT ISSUEESPERIENZE DERMATOLOGICHE

A Journal on Dermatology

Journal of Istituto Dermatologico San Gallicano
Official Journal of the Associazione Dermatologi Ospedalieri Italiani - A.D.O.I.
Indexed/Abstracted in: EMBASE, Scopus

Frequency: Quarterly

ISSN 1128-9155

 

Esperienze Dermatologiche 2016 March;18(1):34-7

    SPECIAL ARTICLES

Acne, antibiotic therapy and antibiotic-resistance: the position of Italian dermatologists

Vincenzo BETTOLI 1, Paola ANTONIOLI 2, Mauro BARBARESCHI 3, Mario BELLOSTA 4, Silvia M. CAMMARATA 5, Antonio DI PIETRO 6, Lorenzo DRAGO 7, Marco LIBANORE 8, Carlo PELFINI 9, Sandra PETRAGLIA 5, Cecilia PRAVETTONI 10, Rita ROSSI 11, Nevena SKROZA 12, Giulia TONI 1, Stefano VERALDI 13, Stefania ZAULI 1, Annarosa VIRGILI 1

1 Dipartimento di Scienze Mediche, Sezione di Dermatologia e Malattie Infettive, Azienda Ospedaliero-Universitaria, Università degli Studi di Ferrara, Ferrara, Italia; 2 Direzione Sanitaria, Azienda Ospedaliero-Universitaria di Ferrara, Ferrara, Italia; 3 Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Fondazione I.R.C.C.S. Cà Granda, Ospedale Maggiore Policlinico, Milano, Italia; 4 Libero professionista, Pavia, Italia; 5 Agenzia Italiana del Farmaco (AIFA), Roma, Italia; 6 Istituto Dermoclinico Vita Cutis, Milano, Italia; 7 Laboratorio di Analisi Cliniche e Microbiologiche, I.R.C.C.S. Ospedale Galeazzi, Milano, Italia; 8 Unità Operativa Complessa Malattie Infettive, Azienda Ospedaliero-Universitaria di Ferrara, Ferrara, Italia; 9 Libero professionista, Como, Italia; 10 Associazione Italiana Dermatologi Ambulatoriali (AIDA), Milano, Italia; 11 Struttura Semplice Dipartimentale di Microbiologia, Azienda Ospedaliero-Universitaria di Ferrara, Ferrara, Italia; 12 Unità Operativa Complessa Dermatologia Universitaria “D. Innocenzi”, Dipartimento Scienze e Biotecnologie Medico-Chirurgiche, Polo Pontino, Facoltà di Farmacia e Medicina, Università Sapienza di Roma, Roma, Italia; 13 Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Fondazione I.R.C.C.S. Cà Granda, Ospedale Maggiore Policlinico, Milano, Italia

The occurrence of bacterial antibiotic resistance is a physiological event and it is increasingly important concern all over the world, which has alarmed the Authorities for Health. Acne is an inflammatory disease that develops within the pilo-sebaceous follicles. Several factors intervene in the development of the disease. Among the others, there is P. acnes, a Gram positive, anaerobic-optional bacterium which can induce inflammatory processes that may lead to the development of acne lesions. Among the different therapeutic options for acne, antibiotics play a relevant role. Analyzing the details of the practical aspects which correlate antibiotic therapy and acne and the problem of antibiotic resistance, four points must be considered separately: 1) the relationship between P. acnes and acne; 2) the systemic infections induced by P. acnes; 3) the relationship among antibiotic drugs, P. acnes and other bacteria different from P. acnes, along with the modification of bacterial environment and induction of resistance; 4) the relationship among antibiotics in acne, antibiotic resistance and possible increased risk of bacterial infections (not by P. acnes). Considering the available data on this topic, the possible side effects related to the drugs that may substitute antibiotics and the benefits provided by antibiotics in acne, it is believed that their use is indicated and reasonable provided that specific prescription rules must be followed.

language: Italian


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