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A Journal on Dermatology

Journal of Istituto Dermatologico San Gallicano
Official Journal of the Associazione Dermatologi Ospedalieri Italiani - A.D.O.I.
Indexed/Abstracted in: EMBASE, Scopus



Esperienze Dermatologiche 2016 March;18(1):30-3


language: Italian

Safety and efficacy assessment of a new intimate cleanser with Oenothera biennis oil, hyaluronic acid and chlorhexidine 0.3% (Antrosil) used in treatment of idiopathic anal itching

Carmine ANTROPOLI 1, Massimo ANTROPOLI 2, Raffaele OTTAIANO 3, Giuliana BOCCIA 3, Francesco GRANT 3, Luigi BOCCIA 4

1 Unità Operativa di Chirurgia 3, A.O.R.N. Antonio Cardarelli, Napoli, Italia; 2 Unità Operativa Complessa di Chirurgia d’Urgenza, A.O.R.N. Antonio Cardarelli, Napoli, Italia; 3 Dipartimento di Ricerca e Sviluppo, New.Fa.Dem Srl, Giugliano, Napoli, Italia; 4 Unità Operativa Semplice di Dermatologia, A.O.R.N. Sant’Anna e San Sebastiano, Caserta, Italia


We evaluated the action synergy of the Oenothera biennis oil, hyaluronic acid and chlorhexidine 0.3%, active ingredients of a new intimate cleanser called Antrosil. The clinical trial was conducted in a randomized double-blind controlled study, in 47 patients with idiopathic itching that complaining of itching in the anus-perineal area without other apparent cause. The patch test of the individual active ingredients at 48 and 72 hours were negative. Two patient populations have been created that complain idiopathic anal itching; 47 patients were recruited for this purpose, 25 male and 22 female divided into the two groups: Group A (experimental arm) and Group C, the control group. In all 24 patients from group A who used the intimate cleanser under study, the itching has subsided or disappeared in the three weeks of treatment; the other arm of the study including 23 patients used a detergent with only chlorhexidine 0.3% have obtained a slight and temporary improvement in pruritus.

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