Total amount: € 0,00
Rigano L. 1, Maramaldi G. 2, Bonfigli A. 3, Togni S. 2, Meneghin M. 2, Brancato S. 3
1 Industrial Consultant and researcher, Milan, Italy;
2 Indena S.p.A, Milan, Italy;
3 ISPE, Milan, Italy
The extract of Boswellia (B.) serrata showed clinical activity in the treatment of different chronic inflammatory diseases, and have been shown to treat clinical manifestations of photoaging on facial skin and radiotherapy skin damage in breast cancer patients. In this pilot study we investigated the efficacy of an emulsion containing olibanum extract (Bosexil®, Boswellia Phytosome®) in the prevention of UV damage in healthy volunteers, as well as in soothing and repairing a physically and mechanical-damaged skin. The effect of the active Boswellia emulsion was compared against a base cream emulsion and with an untreated area in a single-blind study. In total, 30 healthy volunteers were enrolled. Each volunteer was subjected to both physical (UV) and mechanical (stripping test) damage. Transepidermal water loss, blood micro-flow and skin redness were evaluated at different times. Overall, the instrumental measures showed the efficacy of the active Boswellia formulation as a preventive agent for UV damage. Moreover, the results of the mechanical damage test evidenced a faster skin recovery of the area. Collectively, these findings do suggest a potential protective effect of B. serrata extracts on skin damage. Larger trials on pathological conditions are warranted to further evaluate the protective effect of a B. serrata-based cream on skin damage.