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A Journal on Dermatology

Journal of Istituto Dermatologico San Gallicano
Official Journal of the Associazione Dermatologi Ospedalieri Italiani - A.D.O.I.
Indexed/Abstracted in: EMBASE, Scopus



Esperienze Dermatologiche 2015 September;17(3):111-3

language: Italian

Lower limbs’ pilomatricoma

Bertolini A. 1, Percudani C. 2, Ricci R. 3

1 Ambulatorio Dermatologico, Casa della Salute (CDS) di Colorno Torrile, Distretto di Parma, AUSL di Parma, Parma, Italia;
2 Ambulatorio Ulcere Trofiche, Casa della Salute (CDS) di Colorno Torrile, Distretto di Parma, AUSL di Parma, Parma, Italia;
3 Istituto di Anatomia Patologia, Università degli Studi di Parma, Parma, Italia


Pilomatrixoma, also known as Malherbe calcifying epithelioma, is a cutaneous neoplasia that originates from the matrix of the hair follicle. It appears as a hard, but movable lump under the skin, with lobular surface. It grows slowly and it presents with “the tent sign” (skin taking an angular shape when compressed between two fingers) or “the wrinkle sign” when the edges of the injury are slightly compressed between the thumbs, perpendicularly to the lines of least skin tension. Most polimatricomas occur during childhood, mainly among women, or in-between the age of 60 and 80. Pilomatricomas occur most often on the head or neck, less frequently on the arms and rarely on the legs. Histological examinations show a well-defined subcutaneous injury, consisting of basal cells and “ghost” cells, with peripheral mesenchymal fibroblastic elements and variable amount of calcified material and, at times, ossification.

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