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Berruti V., Cardinali C., Gimma A., Taviti F.
U.O.S Dermatologia e Venereologia, Ospedale Misericordia e Dolce, Prato
According to literature, pregnancy seems to exert beneficial effects on acne vulgaris, since estrogens are able to suppress sebum hyper-production. However, some cases have been reported so far describing a severe clinical course of acne in pregnancy, mostly if acne occurs during the first trimester. Such cases also report a relapsing-remitting course of acne, since an improvement of lesions has been reported during the second and third trimester of pregnancy, followed by a sudden worsening after delivery. Thus, the clinical course and the treatment of acne occurring during pregnancy are at present controversial, since several concerns regarding benefits or potential risks exist. The treatment of acne during pregnancy aims to minimize symptoms and to reduce the severity of acneic lesions. This review summarizes the current knowledge regarding the main topical and systemic treatments of acne developing in pregnancy, focusing on the main indications, contraindications and potential side effects of each treatment, according to FDA guidelines.