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Cannarozzo G. 1, 2, Morini C. 1, 2, Sannino M. 2, 3, Campolmi P. 4, Nisticò S. P. 1, 5
1 Department of Dermatology, Tor Vergata University of Rome, Rome, Italy;
2 GILD-FTP (Gruppo Italiano Laser Dermatologia Formazione Teorico Pratica), Rome, Italy;
3 Unit of Dermatologic Surgery and Cutaneous Oncology, ASL Napoli 3 Sud, Italy;
4 Department of Dermatology, University of Florence, Florence, Italy;
5 Department of Health Sciences, University of Catanzaro, Catanzaro, Italy
AIM: Mupirocin is widely used for the topical treatment of infections. Gentamicin is an interesting alternative for both gram-positive and gram-negative bacteria. Aim of this open study was to compare effectiveness and comfort of mupirocin 2% ointment (excipients: macrogol 400 g/mol and 3350 g/mol - PEG ointment) versus gentamicin 0.1% ointment (excipients: liquid paraffin and white soft paraffin) in postoperative injuries caused by ablative and non-ablative lasers.
METHODS: Forty subjects with a variety of benign cutaneous and mucous lesions, localized in different anatomical sites, were enrolled. Patients were treated with ablative (10.600 nm wavelength) CO2 laser, microablative CO2 laser with bipolar radio frequency (RF), 595 nm dye laser, and 532-1064 nm Q-switched (QS) Nd:Yag laser. Patients were divided into two groups for the postoperative management: the first group was treated with daily applications of mupirocin 2% ointment and the second one with daily applications of gentamicin 0.1% ointment.
RESULTS: Patients undergoing ablative CO2 laser removal of skin lesions showed complete resolution of the wounds, absence of permanent atrophic or hypertrophic scarring, absence of dyschromia and no infectious complications. Moreover, patients treated with combined microablative CO2 laser and bipolar RF or with non ablative lasers showed complete healing. Both antibiotic ointments were well tolerated without any cutaneous adverse side effect.
CONCLUSION: Our study, based on a relatively small number of patients, focused primarily on assessing safety and comfort of the two different antibiotic ointments. The peculiar PEG vehicle contained in the mupirocin 2% formulation assures an effective, safe and comfortable profile to this ointment in postlaser wound management even if the antibacterial activity may be comparable to gentamicin 0.1%.