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A Journal on Dermatology

Journal of Istituto Dermatologico San Gallicano
Official Journal of the Associazione Dermatologi Ospedalieri Italiani - A.D.O.I.
Indexed/Abstracted in: EMBASE, Scopus



Esperienze Dermatologiche 2015 June;17(2):43-5

language: English

Dermoscopic and histopathological features of solitary Langerhans’ cell histiocytosis in a child

Stanganelli I. 1, Medri M. 1, Neri I. 2, Barisani A. 2, Passarini B. 3, Varotti E. 2, Patrizi A. 2

1 Skin Cancer Unit, IRCCS IRST, Istituto Scientifico Romagnolo per lo Studio e la Cura Tumori, Meldola, Forlì-Cesena, Italy;
2 Unit of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, Università di Bologna, Bologna, Italy;
3 Laboratory of Dermatopathology, Department of Dermatology, University of Bologna, Bologna, Italy


Langerhans’ cell histiocytosis (LCH) summarizes a spectrum of diseases on the basis of histopathological criteria. It is characterized by an accumulation and proliferation of cells with Langerhans’ cell phenotype, affecting one or multiple organs. Up to 50% of patients with either single-system or multiorgan disease, initially present with cutaneous manifestations. The clinical presentation varies from a single-system unifocal bone or skin disease to a disseminated disease. The diagnosis is confirmed by histopathology and immunohistochemistry. We report a case of LCH in a 6-year-old boy, diagnosed thanks to dermoscopy and histopathological examination. Dermoscopy may represent a useful tool to improve the recognition of LCH and in the follow-up of this disease, particularly in paediatric patients.

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