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Fabbrocini G. 1, Cacciapuoti S. 1, Donnarumma M. 2, Marasca C. 1, Monfrecola G. 1
1 Sezione di Dermatologia Clinica, Allergologica e Venereologica, Dipartimento di Patologia Sistematica, Università di Napoli Federico II, Napoli, Italia;
2 Dipartimento di Terapia Medica, Università “La Sapienza”, Roma, Italia
Acne is a multifactorial dermatosis in which different factors contribute to the maintenance of the inflammatory process. The role of P. acnes has been, in fact, considered as main triggers of the inflammatory response, being able to activate the release of many proinflammatory cytokines. For these reasons, antibiotics are among drugs more frequently used for acne topical therapy. Their use is, however, limited by the development of bacterial resistance. The need of new molecules, whose antibacterial properties are not susceptible to resistance phenomena, is increasing. Among the molecules that have stimulated greater interest for the not antibiotic-dependent antibacterial action, and, therefore, without the risk of antibiotic-resistance development, we include lauric acid, micronized silver and zinc acetate. The aim of this study was to evaluate the efficacy of lauric acid, micronized silver and zinc acetate topic agent in the treatment of mild-to-moderate acne, using both objective evaluation, with GAGS and Sebutape®, and subjective, with a new tool for assessing the psychological impairment of acne patients: acne radar.