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Fabbrocini G., Panariello L., Izzo R., Caro G.
Sezione di Dermatologia, Dipartimento di Medicina Clinica e Chirurgia, Allergologia e Venereologia, Università degli studi di Napoli Federico II, Napoli, Italia
AIM: Recent research into the mechanisms underlying overweight and obesity have shown a positive correlation between the amount of triglycerides deposited inside the adipocytes of white adipose tissue and overweight. The onset of overweight appears to be due to a change in the composition of dietary fatty acids. We evaluated the efficacy and tolerability of combination therapy with a topical product and an oral supplement formulated according to the principles of lipidomics in the treatment of localized adiposity and overweight.
METHODS: The study population was 40 females (20 with localized adiposity and 20 overweight). Ten of the women with localized adiposity received an oral supplement and the topical product (group A1); 10 women received only the oral supplement (group A2). All 20 women received a diet provided by the National Research Council. Ten of the women with overweight received the oral supplement and the diet provided by the National Research Council; 10 women received only the diet. Anthropomorphic data were collected for circumference measurement of the right arm, chest, waist, thighs, right hip and knee, body weight, and body-mass index (weight in kilograms divided by the square of the height in meters). Further assessment included ultrasonography of the subcutaneous tissues in the adipose areas and evaluation of the tolerability of products as measured by a self-report questionnaire.
RESULTS: Ultrasound showed a reduction in hyperechoic density at the dermal-hypodermal border and a reduction in hyperechoic vascular connective tissue bands, which was greater in the group (group A1) which received combined therapy with the topical product, the oral supplement, and diet than in the group (group A2) which received only the oral supplement and diet. Administered in combination with diet, the oral supplement and the topical product were found to significantly reduce body weight, circumference, and thickness of adipose panniculus.
CONCLUSION: The results are significant and may lay the basis for a new therapeutic strategy which merits further study.