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A Journal on Dermatology

Journal of Istituto Dermatologico San Gallicano
Official Journal of the Associazione Dermatologi Ospedalieri Italiani - A.D.O.I.
Indexed/Abstracted in: EMBASE, Scopus



Esperienze Dermatologiche 2013 December;15(4):181-4

language: Italian

Half-face evaluation of regenerative and reparative properties of a serum containing the secret of Cryptomphalus aspersa 15% (SCA) versus placebo, in two groups of patients with acne and photoaging treated with chemical peeling

Sisto T., Bussoletti C., Celleno L.

Clinica Dermatologica Complesso Integrato Columbus, Università Cattolica del Sacro Cuore, Roma, Italia


The secretion of Cryptomphalus aspersa (SCA), a snail present in the Mediterranean area and South America, has powerful anti-inflammatory mechanisms, thanks to its rich content of proteins and polysaccharides. It was initially tested in patients treated for radiodermatitis, showing excellent results in terms of re-epithelialization. Its regenerative and antioxidant properties have been subsequently studied with important applications in the treatment of photoaging. Basing on these data, we evaluated the regenerative post- peeling activity, the timing of re-epithelialization, the effects post treatment and cosmetic sensation of SCA versus placebo in 20 patients undergoing chemical peeling for acne or photoaging. The results obtained documented: a clear regenerative and restorative post- peeling activity, a reduction of post treatment side effects and a cosmetic acceptability of SCA, confirming its efficacy, safety and tolerability.

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