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A Journal on Dermatology
Esperienze Dermatologiche 2013 September;15(3):123-7
Remission induction of Behçet’s disease with cyclosporin in a Chinese patient with hepatitis B virus
Gori A., Cardinali C., Gimma A., Schincaglia E., Fabroni C., Lo Scocco G.
Dermatology Unit, Prato Hospital, USL 4, Italy
Behçet disease (BD) is a chronic, multisystemic, inflammatory disorder with unknown etiology, characterized by recurrent oral and genital ulcerations and ocular lesions. Corticosteroids and immunomodulators are traditionally used to treat BD, but there are currently no standard guidelines for treating patients with this vasculitis. We report the case of a Chinese patient with BD and infected with hepatitis B virus (HBV), who was successfully treated with cyclosporin A (CsA) and lamivudine in our clinic. CsA is the mainstay of treatment of severe BD, particularly for both ocular and mucocutaneous manifestations. In our HBV-positive patient, in spite of CsA-induced immunosuppression, we observed no worsening in liver function. We report this case, because CsA therapy meets the most important key-points in the association between BD and HBV: the excellent clinical response obtained with CsA, the absence of side effects and, at the same time, no worsening of chronic infectious disease.