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A Journal on Dermatology

Journal of Istituto Dermatologico San Gallicano
Official Journal of the Associazione Dermatologi Ospedalieri Italiani - A.D.O.I.
Indexed/Abstracted in: EMBASE, Scopus



Esperienze Dermatologiche 2013 September;15(3):115-7

language: Italian

Grover’s disease

Pesapane F., Menicanti C., Nazzaro G., Vaira F., Coggi A., Gianotti R.

Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italia


Grover’s disease is a primary acantholytic skin disorder that manifests as pruritic, discrete, edematous papules and/or a vesiculopapular rash of the upper trunk. Also known as transient acantholytic dermatosis, Grover disease is characterized by 4 different acantholytic histologic patterns and it has been associated with numerous disorders, including hematologic malignancies. While generally accepted to be a benign, self-limited disorder, it is often persistent and difficult to manage, hence, the description of transient entity is misleading. We present a case of Grover’s disease occurred on a 34 year-old woman with multiple papules with vesicular surface located in the chest, back and also face, that is usually spared by the transient acantholytic dermatosis.

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